◀ Back to IL12B

IL12B — NOS2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL12 complex (IL12A-IL12B) → NOS2 (NOS2) (modification, collaborate) Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12-mediated signaling events: NOS2 (NOS2) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, activates)
  Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Schopf et al., Parasite Immunol 2001 (Disease Models, Animal...) : Interestingly, iNOS was not induced in the lymph node by IL-12 , yet, nitric oxide is critical in the control of leishmaniasis ... However, we observed an increase in iNOS at the lesion site in response to IL-12 ... IL-12 induced iNOS at the lesion site and an early granulomatous inflammation in the lymph node ; therefore, we hypothesize that these are key events responsible for the resolution of disease in BALB/c mice treated with IL-12
Svensson et al., Microb Pathog 2001 : Furthermore, co-incubating S. typhimurium with Mphi resulted in interleukin (IL)-12p40 , IL-6 and tumor necrosis factor-alpha production as well as iNOS induction while IL-12p70 was not detectable
Verma et al., Transplantation 2006 : The mechanism by which IL-12p70 induced delayed rejection was examined by reverse transcription polymerase chain reaction of cytokine mRNA and studying the role of interferon (IFN)-gamma and inducible nitric oxide synthase (iNOS) that were induced by IL-12
Jana et al., Glia 2009 (MAP Kinase Signaling System) : IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1 ... Earlier we have demonstrated that IL-12 p40 homodimer ( p40 ( 2 ) ) induces the expression of inducible nitric oxide synthase (iNOS) in microglia ... This study was undertaken to investigate underlying mechanisms required for IL-12 p40 ( 2 ) - and IL-12 p70 induced expression of iNOS in microglia
Fagundes et al., PLoS Negl Trop Dis 2011 (Dengue...) : Therefore, IL-12/IL-18 induced IFN-? production and consequent NOS2 induction are of major importance to host resistance against DENV infection
Giovannini et al., Microb Pathog 2012 (Tuberculosis) : It induced significantly less IFN-?, IL-12 and IL-27 transcription than wt in infected MDM, while it increased the transcription of inducible NOS
Melby et al., Infect Immun 1998 (Leishmaniasis, Cutaneous...) : Progressive splenic parasitism was associated with an early IL-4 response, markedly increased IL-10 but minimal IL-12 expression, and delayed expression of iNOS