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NOS2 — TLR4

Pathways - manually collected, often from reviews:

• KEGG Leishmaniasis: TLR2/TLR4 → NOS2 (protein-protein, activation)

Text-mined interactions from Literome

Brightbill et al., Science 1999 : Several lipoproteins stimulated TLR dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway
Frost et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : These data indicate that LPS increases NOS2 mRNA expression in muscle via a TLR4 dependent mechanism
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2) ... A critical role in the mtDNA damage was determined for TLR4 mediated iNOS transcription through the MyD88 pathway
Lee et al., Biochem Pharmacol 2005 : Together, these results demonstrate that STKs play a positive regulatory role in TLR4 mediated iNOS expression in a MyD88 independent ( TRIF dependent ) manner
Copin et al., J Immunol 2007 (Brucellosis) : Using genetically deficient mice, we demonstrated that the induction of iNOS and IFN-gamma producing cells due to Brucella infection required TLR4 and TLR9 stimulation coupled to Myd88 dependent signaling pathways
Uno et al., Am J Physiol Gastrointest Liver Physiol 2007 (Helicobacter Infections) : The induction of iNOS and the associated nitric oxide production in response to H. pylori-LPS stimulation were inhibited by declines in not only TLR4 but also TLR2
Tsukamoto et al., J Immunol 2008 : Previous pharmacologic studies have suggested that a PI3K-Akt pathway negatively regulates TLR induced inducible NO synthase expression and cytokine production
Masamune et al., J Gastroenterol 2008 : TLR ligands induced expression of monocyte chemoattractant protein 1, cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible nitric oxide synthase , but not proliferation or type I collagen production
Zhang et al., J Neuroimmunol 2010 : In LPS treated primary SCs, retreatment with PPAR-gamma agonist remitted the increase of iNOS , p38 phosphorylation and TLR4 , MyD88, augmented the expression of PPAR-gamma and localization in nuclear
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach
Shweash et al., Mol Immunol 2011 (Leishmaniasis) : Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression ... Induction of COX-2 and iNOS was also TLR-4 dependent ... These data demonstrate for the first time the role of TLR-4 in mediating the effects of L. mexicana promastigotes on MAP kinase activation, up-regulation of COX-2, iNOS as well as arginase-1 expression in macrophages and further shows that PGE ( 2 ), NO and arginase activity all contribute substantially to the inhibition of host cell IL-12 production
Peng et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Inflammation) : TLR4 inhibition reduced LPS induced upregulation of inducible nitric oxide synthase (iNOS) and ICAM-1 as well as PARP1
Brieger et al., J Immunol 2013 : Chelation of Zn ( 2+ ) with the membrane-permeable chelator N, N,N ', N'-Tetrakis ( 2-pyridylmethyl ) ethylenediamine augmented TLR4 mediated production of IFN-ß and subsequent synthesis of inducible NO synthase and production of NO