Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gibbs et al., Int J Biochem Cell Biol 2012 (Congenital Disorders of Glycosylation...) : Furthermore, we observed that nitric oxide synthase activity was dependent on mTOR in these myeloid cells and involved in HIF-1a accumulation mediated by endosomal toll-like receptor 7/8 triggering in THP-1 cells as well as IgE dependent basophil, but not mast cell, responses
Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells
Partovian et al., Mol Cell 2008 : Reduced mTORC2 activity in S4 ( -/- ) endothelial cells results in decreased FoxO1/3a and eNOS phosphorylation, decreased endothelial cell size, and increased arterial blood pressure in S4 ( -/- ) mice
Kim et al., Am J Physiol Endocrinol Metab 2012 : An inhibitor of mTOR , rapamycin, attenuated the ANG II-stimulated phosphorylation of p70S6K and phosphorylation of IRS-1 ( Ser ( 636/639 ) ) and blocked the ability of ANG II to impair insulin stimulated phosphorylation of eNOS , nitric oxide production, and mesenteric-arteriole vasodilation