Gene interactions and pathways from curated databases and text-mining

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NOX5 — TP53

Text-mined interactions from Literome

Zhao et al., Carcinogenesis 2006 (Cell Transformation, Neoplastic...) : Inhibition of NADPH-oxidase ( NOX ) by diphenyleneiodonium suppressed p53 activation and apoptosis in 308 cells, linking Ras mutation to NOX induced p53 activation, which was further supported by the finding that siRNA to Rac1 inhibited p53 activation after TPA treatment
Jeon et al., FEBS Lett 2010 (Colonic Neoplasms) : Additionally, NADPH oxidase ( NOX ) inhibitor apocynin and p22(phox) siRNA significantly reduced p53 expression and suppressed the appearance of senescence markers