◀ Back to NOX1
NOX1 — NOXO1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP complex (RAC1)
→
RAC1/GTP/NOX1/NOXA1/NOXO1 complex (RAC1-NOX1-NOXA1-NOXO1)
(modification, collaborate)
Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
Evidence: assay, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP complex (RAC1)
→
NOX1/NOXA1/NOXO1 complex (NOX1-NOXA1-NOXO1)
(modification, collaborate)
Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
Evidence: assay, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP/NOX1/NOXA1/NOXO1 complex (RAC1-NOX1-NOXA1-NOXO1)
→
NOX1/NOXA1/NOXO1 complex (NOX1-NOXA1-NOXO1)
(modification, collaborate)
Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cheng et al., J Biol Chem 2004
:
Nox1 , a homolog of gp91(phox), is
regulated by
NOXO1 and NOXA1, homologs of p47(phox) and p67(phox), respectively
Meng et al., Inhal Toxicol 2006
(Disease Models, Animal...) :
NOXO1 , which was upregulated in all three treatment groups, positively
regulates the expression of a subunit of
NADPH oxidase ( NOX1 ), a major source of reactive oxygen species, and may play an important role in the pathogenesis of COPD
Miyano et al., J Biol Chem 2006
:
We also demonstrate that Nox1 activation requires membrane recruitment of Noxa1, which is normally mediated via Noxa1 binding to Noxo1, a protein tethered to the Nox1 partner p22(phox) : the
Noxa1-Noxo1 and Noxo1-p22(phox) interactions are both
essential for
Nox1 activity
Takeya et al., FEBS J 2006
:
Activation of the superoxide producing NADPH oxidase
Nox1 requires both the organizer protein
Noxo1 and the activator protein Noxa1
Kawahara et al., BMC evolutionary biology 2007
:
Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac,
activate Nox1 , a non-phagocytic homolog of Nox2
Choi et al., J Biol Chem 2008
:
Ang II enhanced the activity of both Nox1 and
Nox2 supported by either adaptor pair, with more effective activation of Nox1 in the
presence of
NOXO1 and NOXA1 and of Nox2 in the presence of p47(phox) and p67(phox)
Kuwano et al., Free Radic Biol Med 2008
:
Interleukin-1beta, flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly
induced Nox1 in a colon cancer cell line ( T84 ), whereas only TNF-alpha fully induced
NOXO1 and upregulated superoxide producing activity by ninefold
Dutta et al., PloS one 2010
:
NOX1 , an NADPH oxidase homologue that is most abundantly expressed in colon epithelial cells,
requires the regulatory subunits
NOXO1 ( NOX organizing protein 1 ) and NOXA1 ( NOX activating protein 1 ), as well as the flavocytochrome component p22(phox) for maximal activity