Gene interactions and pathways from curated databases and text-mining

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CASP10 — NPM1

Text-mined interactions from Literome

Chou et al., Mol Pharmacol 2001 (Cell Transformation, Neoplastic) : Cell permeable caspase-3 inhibitor added in the medium blocked the decrease of nucleophosmin/B23 and apoptosis induced by serum deprivation in NIH-3T3 cells
Leong et al., Blood 2010 : Here, we demonstrate a gain-of-function role for cytoplasmic NPM in the inhibition of caspase signaling
Wang et al., Mol Cell Biol 2013 (Ischemia...) : Expression of a cytosol restricted NPM mutant ( NPM-dNLS ), but not a nucleus restricted NPM mutant, increased NPM-Bax complex formation, mitochondrial NPM and Bax accumulation, mitochondrial membrane injury, caspase 3 activation, and ischemia induced cell death