Gene interactions and pathways from curated databases and text-mining

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ANG — NPPA

Text-mined interactions from Literome

Yamakawa et al., Am J Physiol Heart Circ Physiol 2000 (Hypertrophy, Left Ventricular) : We investigated the effects of diastolic wall stress ( WS ) and angiotensin II (ANG II) on the left ventricular ( LV ) hypertrophy ( LVH ) induced by volume overload and on the gene expression of LV adrenomedullin (AM) and atrial natriuretic peptide (ANP) in volume overload
Heintz et al., Clin Physiol Biochem 1992 (Heart Failure) : Conclusion : ACE inhibition does not induce changes in ANP or ADH levels in the resting state while Ang II decreases
Kohno et al., Kidney Int 1992 : Rat ANP ( 1-28 ) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration dependent manner
Ruzicska et al., J Hypertens 2004 (Diabetes Mellitus, Experimental...) : Left ventricular levels of ANP and BNP mRNA were increased by Ang II in diabetic animals more than the additive effects of diabetes and Ang II alone, showing that Ang II induced an amplified response with respect to cardiac concentrations of ANP and BNP in diabetes
Guo et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2005 (Cardiomegaly) : The effective ingredients of Chinese herbs for promoting blood circulation, DSS and TMZ, have the effect of inhibiting the hyper-expression of ANP and beta-actin induced by Ang II, and preventing myocardial hypertrophy, therefore, it could be used to prevent and treat cardiomegaly
Shimoni et al., Am J Physiol Heart Circ Physiol 2006 (Diabetes Mellitus, Experimental...) : In male diabetic V cells, in vitro ANP ( 300 nM-1 muM, > 5 h ) decreases oxidative stress and augments K ( + ) currents, but not when excess ANG II is present
Shah et al., Am J Physiol Heart Circ Physiol 2010 : The aim of the present study is to explain the modulatory role of ANG- ( 1-7 ) in atrial natriuretic peptide (ANP) secretion and investigate the functional relationship between two peptides to induce cardiovascular effects using isolated perfused beating rat atria and a cardiac hypertrophied rat model ... ANG- ( 1-7 ) ( 0.01, 0.1, and 1 muM ) increased ANP secretion and ANP concentration in a dose dependent manner at high atrial pacing ( 6.0 Hz ) with increased cGMP production
Shah et al., Peptides 2010 (Diabetes Mellitus, Experimental) : However, the inhibitory effect of Ang- ( 1-7 ) on the hyposmolarity induced ANP secretion was not observed in the DM atria ... Taken together, we concluded that Ang- ( 1-7 ) attenuated hyposmolarity induced ANP secretion via the Na ( + ) -K ( + ) pump and a lack of Ang- ( 1-7 ) response in DM atria may partly relate to change in Na ( + ) -K ( + ) pump activity
Oh et al., Peptides 2011 (Cardiomyopathy, Hypertrophic...) : The aim of the present study is to test whether Ang II affects stretch induced ANP secretion ... The suppressive effect of Ang II on stretch induced ANP secretion was blocked by the pretreatment of losartan but not by the pretreatment of PD123319 or A779
Shimamoto et al., J Cardiovasc Pharmacol 1989 : To clarify the effects of norepinephrine and angiotension II (Ang II) on plasma atrial natriuretic peptide (ANP) , both pressor substances were infused into normal volunteers, and plasma ANP levels and venous return were determined
Klemm et al., J Hypertens Suppl 1987 (Adenoma...) : When ANG II infusion stimulated ANP, it also raised blood pressure, which could therefore be mediating the effects of ANG II on ANP
Mann et al., Klin Wochenschr 1986 : We investigated the effects of inhibition of angiotensin II (ANG II) formation with an ANG I converting enzyme inhibitor, namely Enalapril, on circulating levels of atrial natriuretic peptide (ANP)
Soualmia et al., Life Sci 1996 : This study presents an investigation of the mechanism of angiotensin II (Ang II) induced atrial natriuretic peptide (ANP) release in superfused sliced right atria of rats
Stockand et al., Am J Physiol 1996 : Experiments were performed to determine the role of BKCa in the regulation by vasorelaxants of mesangial contraction measured as percent maximal and defined by reduction in length induced by replacing 135 mM bath NaCl with KCl. Contraction by ANG II ( 100 nM = 60.5 % ) was attenuated by NP ( 100 microM ), ANP ( 1.0 microM ), and DBcGMP ( 10 microM ) in the absence, but not the presence, of iberiotoxin, a specific inhibitor of BKCa
Soualmia et al., J Cardiovasc Pharmacol 1997 : The effect of angiotensin II (Ang II) on inositol phosphate ( IP ) production and atrial natriuretic peptide (ANP) release was studied in sliced rat atrial tissue ... Stimulation of ANP release by Ang II was dependent on intracellular Ca2+