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HDAC2 — NR4A1

Text-mined interactions from Literome

Liu et al., Int J Oncol 2009 (Leukemia) : The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression
Zhou et al., Leukemia 2013 (Leukemia, Myeloid, Acute) : HDAC inhibition by SNDX-275 ( Entinostat ) restores expression of silenced leukemia associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML ... We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1