Gene interactions and pathways from curated databases and text-mining

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MAPK1 — NR4A1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kovalovsky et al., Mol Endocrinol 2002 (MAP Kinase Signaling System) : The MAPK kinase inhibitors did not affect Nur77 and Nurr1 mRNA induction but blocked CRH or cAMP stimulated Nur transcriptional activity
Fujii et al., Genes Cells 2008 : Here we demonstrate that the MAPK induced phosphorylation of Nur77 during T cell activation plays a critical role in the induction of apoptosis
Huang et al., Neurosci Lett 2008 (Brain Infarction...) : The induction of c-fos, c-jun, nur77 , and zif268 by hypoxia was inhibited by naloxone ( 0.1 microM ) and MAPK inhibitors ( 10 microM of U0126, D98059, SB203580 )
Shao et al., J Mol Cell Cardiol 2010 (Inflammation) : OxLDL activated the phosphorylation ERK1/2 and p38 MAPK, inhibition of p38 MAPK but not ERK1/2 attenuated Nur77 expression