◀ Back to SHC1

NTRK1 — SHC1

Pathways - manually collected, often from reviews:

• BioCarta role of erk5 in neuronal survival pathway: neurotrophin/TRkA complex (NTF3_BDNF_NGFB-NTRK1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta trka receptor signaling pathway: NGF/TRkA complex (NTRK1-NGFB) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Neurotrophin signaling pathway: NTRK1 → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → SHC (SHC1) (modification, activates) Li et al., Science 1992, Stephens et al., Neuron 1994, Obermeier et al., EMBO J 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → SHC (SHC1) (modification, activates) Meakin et al., J Biol Chem 1999, Ong et al., Mol Cell Biol 2000, Dixon et al., Biochim Biophys Acta 2006, Guiton et al., J Biol Chem 1995, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: SHC1 → NTRK1 (reaction)
• Reactome Reaction: SHC1 → NTRK1 (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: NTRK1 — SHC1 van der Geer et al., Curr Biol 1995*, O'Bryan et al., Proc Natl Acad Sci U S A 1996*, Li et al., J Biol Chem 1996*
• IRef Bind Interaction: SHC1 — NTRK1 van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind Interaction: NTRK1 — SHC1 Stephens et al., Neuron 1994
• IRef Bind_translation Interaction: NTRK1 — SHC1 (coimmunoprecipitation) van der Geer et al., Curr Biol 1995*, O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: NTRK1 — SHC1 (competition binding) O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: NTRK1 — SHC1 (competition binding) O'Bryan et al., Proc Natl Acad Sci U S A 1996*, Li et al., J Biol Chem 1996*
• IRef Bind_translation Interaction: NTRK1 — SHC1 (affinity chromatography technology) O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — NTRK1 (coimmunoprecipitation) van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — NTRK1 (affinity chromatography technology) van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — NTRK1 (surface plasmon resonance) van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — NTRK1 (competition binding) van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: NTRK1 — SHC1 (coimmunoprecipitation) Stephens et al., Neuron 1994
• IRef Biogrid Interaction: NTRK1 — SHC1 (direct interaction, two hybrid) Qian et al., Neuron 1998
• IRef Biogrid Interaction: NTRK1 — SHC1 (physical association, affinity chromatography technology) Borrello et al., Oncogene 1994*
• IRef Biogrid Interaction: NTRK1 — SHC1 (direct interaction, two hybrid) Koch et al., FEBS Lett 2000*
• IRef Biogrid Interaction: NTRK1 — SHC1 (direct interaction, pull down) Meakin et al., J Biol Chem 1999
• IRef Biogrid Interaction: NTRK1 — SHC1 (direct interaction, two hybrid) Nakamura et al., Mol Cell Biol 2002
• IRef Hprd Interaction: Complex of NTRK1-SHC1-PLCG2-NTRK1-SHC1-SHC1-NTRK1-PLCG2-PLCG2 (in vivo) Obermeier et al., J Biol Chem 1993
• IRef Hprd Interaction: SHC1 — NTRK1 (in vitro) Ong et al., Mol Cell Biol 2000, Dikic et al., J Biol Chem 1995*, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
• IRef Hprd Interaction: SHC1 — NTRK1 (in vivo) Ong et al., Mol Cell Biol 2000, Dikic et al., J Biol Chem 1995*, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
• IRef Intact Interaction: NTRK1 — SHC1 (association, competition binding) Obermeier et al., J Biol Chem 1993
• IRef Intact Interaction: NTRK1 — SHC1 (association, coimmunoprecipitation) Obermeier et al., J Biol Chem 1993
• IRef Ophid Interaction: NTRK1 — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

van der Geer et al., Oncogene 1999 : A triple substitution of the -5, -8 and -9 residues relative to Tyr 960 of the IR to the corresponding amino acids found in the Shc PTB domain binding site of TrkA results in even stronger binding of the IR to Shc in vivo
MacDonald et al., J Mol Neurosci 1999 : The interaction with trkA is not affected by mutations at either Tyr499 or Tyr794, the two major phosphotyrosine residues essential to the activation and receptor binding of Shc , FRS-2/SNT, and phospholipase Cgamma-1, and it is highly specific in vitro for trkA, with little or no binding observed with trkB and/or trkC
Foehr et al., J Neurosci 2000 : Conversely a dominant negative mutant of Shc inhibited TrkA but not p75 activation of NF-kappaB