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NFKB1 — ODC1
Text-mined interactions from Literome
Tantini et al., FEBS Lett 2002
:
Here we show an
involvement of
nuclear factor-kappaB (NF-kappaB) in the induction of nitric oxide synthase (NOS) and
ornithine decarboxylase (ODC) , the key enzyme in polyamine biosynthesis
Tacchini et al., Carcinogenesis 2004
(Breast Neoplasms...) :
Hepatocyte growth factor activated
NF-kappaB regulates HIF-1 activity and
ODC expression, implicated in survival, differently in different carcinoma cell lines
Chung et al., Carcinogenesis 2007
(Acute Disease...) :
When mouse skin was treated after TPA induced production of papillomas, xanthorrhizol remarkably suppressed the expression of
ODC , iNOS and COX-2 and
inhibited the activation of
NF-kappaB ... Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of
ODC , iNOS and COX-2
regulated by the
NF-kappaB , mitogen activated protein kinases and/or Akt
Liao et al., Leuk Res 2008
:
Meanwhile conventional expression of
ODC represses tumor necrosis factor-alpha (TNF-alpha) expression and
nuclear factor-kappaB (NF-kappaB) activation as well as MMP-9 enzyme activity ... Furthermore,
ODC could directly inhibit and
attenuate NF-kappaB DNA binding and transcriptional activation