Gene interactions and pathways from curated databases and text-mining

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MAPK4 — OSM

Text-mined interactions from Literome

Halfter et al., Brain Res Mol Brain Res 2000 (Glioblastoma...) : Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells
Thabard et al., Cytokine 2001 (MAP Kinase Signaling System...) : In OPM-2 cells, IL-6, OSM and LIF induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI 3-K) activation
Sohara et al., J Hepatol 2002 (MAP Kinase Signaling System) : PD inhibited OSM mediated stimulation of TIMP-1 protein, mRNA, promoter activity, phosphorylation of MAPK , and TIMP-1 message stability
Langdon et al., J Immunol 2003 (Pulmonary Eosinophilia) : OSM induced ERK-1,2 and p38 mitogen activated protein kinase phosphorylation in NIH 3T3 cells, and inhibitors of ERK ( PD98059 ) or p38 ( SB203580 ) could partially reduce OSM induced eotaxin production, suggesting partial dependence on mitogen activated protein kinase signaling
Salamon et al., J Allergy Clin Immunol 2008 (Sarcoidosis) : OSM was localized to the cytoplasm, and its expression was inhibited by dexamethasone and mitogen activated protein kinase inhibitors
Thoma et al., J Biol Chem 1994 : However, we found that OSM is a much more potent inducer of both mitogen activated protein kinase activity and biological response, both of which correlate with the expression of a second OSM receptor that does not bind LIF
Korzus et al., J Biol Chem 1997 : The mitogen activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element mediated activation of matrix metalloproteinase 1 gene expression
Stancato et al., Mol Cell Biol 1997 : Beta interferon and oncostatin M activate Raf-1 and mitogen activated protein kinase through a JAK1 dependent pathway ... In HeLa cells, both IFN-beta and oncostatin M (OSM) stimulated MAPK and Raf-1 enzyme activity, in addition to Stat1 and Stat3 tyrosine phosphorylation