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GNRH1 — OTX2

Text-mined interactions from Literome

Kelley et al., Mol Endocrinol 2000 : Overexpression of mouse Otx2 in GT1-7 cells induces expression of a GnRH promoter plasmid, an effect that is dependent upon the Otx binding site
Larder et al., J Biol Chem 2009 : Otx2 induction of the gonadotropin releasing hormone promoter is modulated by direct interactions with Grg co-repressors ... Without this physical interaction, Grg4 can not repress Otx2 dependent activation of GnRH gene transcription ... Taken together, these data show that Otx2 is important for GnRH expression and that direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
Dateki et al., J Clin Endocrinol Metab 2010 (Anophthalmos...) : Conclusions : The results imply that OTX2 mutations are associated with variable pituitary phenotype, with no genotype-phenotype correlations, and that OTX2 can transactivate GNRH1 as well as HESX1 and POU1F1
Diaczok et al., Mol Endocrinol 2011 (Hypogonadism...) : Taken together, these data provide in vivo evidence that Otx2 is critical for GnRH expression and reproductive competence