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AKT3 — PAK2

Text-mined interactions from Literome

Tang et al., J Biol Chem 2000 : We found that activated Akt stimulated Pak, whereas a dominant negative Akt inhibited Ras activation of Pak in transfection assays ... Akt stimulation of Pak was not inhibited by dominant negative mutants of either Rac or Cdc42 suggesting that Akt activated Pak through a GTPase independent mechanism
Somanath et al., Oncogene 2009 (Cell Transformation, Neoplastic...) : Importantly, disruption of the function of PAK not only uncoupled the activation of Akt from that of extracellular signal regulated kinases, but also greatly reduced the capacity of Akt to act as a transforming oncogene
Chow et al., PloS one 2010 (Cell Transformation, Neoplastic...) : However, in tumors, loss of Pak activity does not reduce Erk or Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
Ju et al., Cell Signal 2013 : Finally, PAK1/2 is also recruited to the rafts by the S4-PKCa complex and is required for AKT activation
Sato et al., J Gastroenterol Hepatol 2013 : Western blotting analyses showed that TGF-ß stimulated Akt and PAK2 in all three hepatoma cell lines, and phosphorylated PAK2 was blocked by Akt inhibitor