Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Li et al., J Biol Chem 2008 : Inhibition of PI3K or mTOR reduced the level of Rap1B , which acts downstream of Rheb and mTOR
Rodríguez-Vargas et al., Cell Res 2012 : The absence of PARP-1 blunted AMPK activation and prevented the complete loss of mTOR activity, leading to a delay in autophagy
Ethier et al., PloS one 2012 (Necrosis) : In this study, we show that PARP-1 activation and PAR synthesis affect the energetic status of cells, inhibit the mTORC1 signaling pathway and possibly modulate the mTORC2 complex affecting cell fate
Mallon et al., Mol Cancer Ther 2010 : We are testing whether dual PI3K/mTOR inhibitors can durably suppress p-Akt, induce cleaved PARP , and cause tumor regression in a diverse set of human tumor xenograft models
Son et al., Toxicol Appl Pharmacol 2011 : Consequently, these results suggest that cadmium mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells