Gene interactions and pathways from curated databases and text-mining

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FAS — PARP14

Text-mined interactions from Literome

Kobayashi et al., Arthritis Rheum 1999 (Osteoarthritis) : In addition, Fas ligation to TNFalpha treated cultured OA synoviocytes induced activation of caspase 8 and caspase 3, with subsequent cleavage of poly ( ADP-ribose ) polymerase ( PARP ), a substrate of activated caspase 3
Shisler et al., Virology 2001 : The MC159 expressing virus blocked Fas induced activation of caspase-3 and -8, degradation of PARP , and cleavage of DNA, whereas the parental vaccinia virus did not
Starcevic et al., J Natl Cancer Inst 2001 (Breast Neoplasms) : Levels of proteins involved in Fas mediated apoptosis and cleavage of poly ( adenosine diphosphate-ribose ) polymerase ( PARP ), an end product of caspase activation, were determined by immunoblotting
Wagenknecht et al., Cell Death Differ 2001 : CD95L induced caspase 3-like activity, cytochrome c release and cleavage of caspases 3, 8, 9 and poly ( ADP-ribose ) polymerase ( PARP ) increase substantially after cotreatment with CD95L and C2-ceramide compared with CD95L treatment alone
Los et al., Mol Biol Cell 2002 (Necrosis) : TNF but not CD95 mediated PARP activation, whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD
Mou et al., Int J Biochem Cell Biol 2013 (Neoplasms) : Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound Fas and Bax, reduced the expression of Bcl-2, promoted the cleavage of caspases-8, -3, -9 and PARP, and the nuclear translocation of cleaved PARP
Dou et al., J Cell Biochem 1997 : Stimulation of Fas by Fas ligand or agonistic antibodies results in the activation of interleukin-1 beta converting enzyme-like ( ICE-like ) proteases, and proteolytic cleavage of poly ( ADP-ribose ) polymerase ( PARP )