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BCL2 — PDCD11
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Korsmeyer et al., Cancer Res 1999
(Hyperplasia...) :
BCL-2 gene family and the
regulation of
programmed cell death
Dilla et al., Endocrinology 2000
(Carcinoma, Medullary...) :
MDM2 mediated
programmed cell death is at least
mediated by a down-regulation of the antiapoptotic protein
Bcl-2
Hamzaoui et al., Mediators Inflamm 1999
(Behcet Syndrome...) :
Defective regulation of
programmed cell death ( apoptosis ) may play a role in the development of ( BD ), and the proto-oncogene
Bcl-2 is
involved in the control of apoptosis in immunocompetent cells
Koty et al., Lung Cancer 2002
(Carcinoma, Non-Small-Cell Lung...) :
In vivo expression of p53 and
Bcl-2 and their
role in
programmed cell death in premalignant and malignant lung lesions
Ottaviani et al., Cell Biol Int 2002
:
BCL-2 does not
control programmed cell death in the IPLB-LdFB cell line from the insect Lymantria dispar
Munger et al., Virology 2003
:
The
programmed cell death induced by this mutant is
blocked by overexpression of
Bcl-2 or by transduction of infected cells with the gene encoding the viral U ( S ) 3 protein kinase
Vogel et al., Cerebellum 2002
:
The purpose of this review is to summarize recent findings about the
role of
Bcl-2 and Bax in regulating
programmed cell death in the cerebellum during normal development and in a mouse model of cell autonomous and target related cell death, the Lurcher mutant
Pinto et al., J Comput Aided Mol Des 2004
:
Overexpression of Bcl-2 and
Bcl-xL proteins, both
inhibitors of apoptosis or
programmed cell death , is related to the generation and development of several types of cancer as well as to an elevated resistance to chemotherapeutic treatments ... Overexpression of
Bcl-2 and Bcl-xL proteins, both
inhibitors of apoptosis or
programmed cell death , is related to the generation and development of several types of cancer as well as to an elevated resistance to chemotherapeutic treatments
Hu et al., Clin Cancer Res 2004
(Carcinoma, Non-Small-Cell Lung...) :
Overexpression of
Bcl-2 protein in cancer cells can
inhibit programmed cell death and engender chemoresistance
Peterson et al., Hybridoma (Larchmt) 2005
:
Annexin staining in hybridoma 7.16.4 confirmed that apoptosis was the primary means of cell death in this cell line, and expression of Bcl-2-delta and
Bcl-xl-delta inhibited
programmed cell death
Thuduppathy et al., Protein Sci 2006
:
Regulation of
programmed cell death by
Bcl-xL is dependent on both its solution and integral membrane conformations
Boehm et al., Curr Mol Med 2006
(Skin Diseases) :
Experimental evidence suggests a
role for
Bcl-2 and CD95L in the inhibition of
programmed cell death in UV-induced skin cancer or malignant melanoma cells
Schäbitz et al., J Cereb Blood Flow Metab 2008
(Brain Infarction...) :
In primary cortical neurons and human neuroblastoma cells, GM-CSF counteracts
programmed cell death and
induces BCL-2 and
BCL-Xl expression in a dose- and time dependent manner ... In primary cortical neurons and human neuroblastoma cells, GM-CSF counteracts
programmed cell death and
induces BCL-2 and BCL-Xl expression in a dose- and time dependent manner
Nuñez et al., Nature 1991
:
Bcl-2 , an inner mitochondrial membrane protein,
blocks programmed cell death in B cells
Huang et al., Curr Opin Drug Discov Devel 2000
:
Bcl-2 and related proteins
play a central role in the regulation of
programmed cell death or apoptosis implicated in many human diseases
Chand et al., J Immunol 2012
(Chronic Disease...) :
Bcl-2 , a prosurvival protein,
regulates programmed cell death during development and repair processes, and it can be oncogenic when cell proliferation is deregulated
Krajewski et al., Am J Pathol 1995
:
The mcl-1 gene encodes an approximately 37-kd protein that has significant homology with
Bcl-2 , an
inhibitor of
programmed cell death that is expressed in many types of long lived cells
Schena et al., Leukemia & lymphoma 1993
(Leukemia, Lymphocytic, Chronic, B-Cell) :
The
Bcl-2 gene product
regulates programmed cell death and a number of experiments suggest that Bcl-2 is involved in the selection and maintenance of long lived memory B cells rescuing them from apoptotic death and leading to their accumulation in the GO phase of the cell cycle
Park et al., J Acquir Immune Defic Syndr Hum Retrovirol 1996
:
Effects of human immunodeficiency virus type 1 infection on
programmed cell death in the
presence or absence of
Bcl-2
Papadimitriou et al., Eur J Cancer 1997
(Breast Neoplasms...) :
The
Bcl-2 gene product
prevents programmed cell death ( apoptosis ) and possibly promotes tumour development
Li et al., J Biol Chem 1997
:
Bcl-xL , an antiapoptotic member of the Bcl-2 family,
inhibits programmed cell death in a broad variety of cell types
Sheng et al., Cancer Res 1998
(Colonic Neoplasms...) :
Additionally, PGE2 inhibits
programmed cell death caused by SC-58125 and
induces Bcl-2 expression, but did not affect Bcl-x or Bax expression in human colon cancer ( HCA-7 ) cells
Weinstein et al., Oncogene 1998
(Breast Neoplasms) :
Conversely, the transfection of
Bcl-2 into MCF-7 cells
inhibits heregulin mediated
programmed cell death