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MAPK1 — PDGFRB
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nebigil et al., Proc Natl Acad Sci U S A 2000
(MAP Kinase Signaling System) :
Moreover, by using the specific platelet derived growth factor receptor ( PDGFR ) inhibitor AG 1296 or by overexpressing a kinase-mutant PDGFR, we show that
PDGFR kinase activity is
essential for 5-HT2B triggered
MAPK/cyclin D1, but not cyclin E, signaling pathways
Cartel et al., Am J Physiol Lung Cell Mol Physiol 2001
(MAP Kinase Signaling System) :
These results suggest that PDGF-BB mediated activation of
p42(MAPK) requires the
PDGFR-beta but is independent of its tyrosine phosphorylation
Lamy et al., Carcinogenesis 2008
(Neovascularization, Pathologic) :
The inhibitory effect of delphinidin on
PDGFR-beta was very rapid and
led to the inhibition of PDGF-BB induced activation of extracellular signal regulated kinase (
ERK)-1/2 signaling and of the chemotactic motility of SMC, as well as the differentiation and stabilization of EC and SMC into capillary-like tubular structures in a three-dimensional coculture system
Chen et al., Nature 2011
(Diabetes Mellitus, Experimental) :
Targeted human
PDGFR-a activation in mouse ß-cells
stimulated Erk1/2 phosphorylation, leading to Ezh2 dependent expansion of adult ß-cells