Gene interactions and pathways from curated databases and text-mining

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IL10 — PDLIM7

Text-mined interactions from Literome

Vockerodt et al., Virology 2001 (Burkitt Lymphoma...) : Here we demonstrate that IL-10 was specifically induced by the EBV-latent membrane protein 1 (LMP1) in Burkitt 's lymphoma ( BL ) cell lines BL2 and BL41 ... In two T cell lines ( Jurkat, MOLT3 ), two NHL cell lines ( U266, MHH-PREB1 ), or three Hodgkin 's disease ( HD ) cell lines ( L428, L540, and KMH2 ), LMP1 did not induce IL-10 expression ... Inhibition of LMP1 mediated NF kappa B activation by constitutive repressive I kappa B-alpha only marginally impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM ( a specific p38/SAPK2 inhibitor ) led to reduced IL-10 expression
Kis et al., Blood 2006 (Burkitt Lymphoma...) : IL-10 can induce the expression of EBV encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma derived cell lines ... We show now that both human and EBV encoded IL-10 can induce LMP-1 in the absence of EBNA-2 in the Daudi, P3HR1, and other BL cell lines ... IL-10 could also induce LMP-1 in the conditional lymphoblastoid cell line ER/EB2-5 where EBNA-2 was downregulated in the absence of estrogen ... Moreover, IL-10 could induce the expression of LMP-1 in tonsillar B cells infected with the nontransforming, EBNA-2-deficient EBV strain P3HR1 and enhance LMP-1 expression in 2 EBV positive NK lymphoma lines ... The demonstration that IL-10 can induce the expression of LMP-1 in an EBNA-2 independent manner shows that the major transforming EBV gene LMP-1 can be induced by extracellular signals in lymphoid cells, and IL-10 might contribute to the establishment of type II EBV latency
Kis et al., Immunol Lett 2006 (Hodgkin Disease) : IL-10 induced LMP-1 also in tonsillar B-cells infected with the EBNA-2 deleted virus strain P3HR-1
Lambert et al., J Immunol 2007 : However, the mechanisms by which LMP1 induces IL-10 are incompletely understood ... To test the hypothesis that PI3K, which acts upstream of mammalian target of rapamycin, might also be involved in LMP1 dependent IL-10 production, we generated B cell lines expressing signaling-inducible chimeric LMP1 ... We find that GSK3beta regulates LMP1 dependent IL-10 induction, with GSK3beta inhibition by pharmacologic or small interfering RNA strategies enhancing LMP1 induced IL-10 induction
Lin et al., Cytokine 2010 : Here we have identified an important signaling event mediated by a dsRNA dependent serine/threonine protein kinase, PKR, in regulating LMP1 induced IL-6 and IL-10 expression
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production
Nakagomi et al., Int J Cancer 1994 (Burkitt Lymphoma) : The Epstein-Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines