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IL10 — PDLIM7
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Vockerodt et al., Virology 2001
(Burkitt Lymphoma...) :
Here we demonstrate that
IL-10 was specifically
induced by the
EBV-latent membrane protein 1 (LMP1) in Burkitt 's lymphoma ( BL ) cell lines BL2 and BL41 ... In two T cell lines ( Jurkat, MOLT3 ), two NHL cell lines ( U266, MHH-PREB1 ), or three Hodgkin 's disease ( HD ) cell lines ( L428, L540, and KMH2 ),
LMP1 did not
induce IL-10 expression ... Inhibition of
LMP1 mediated NF kappa B activation by constitutive repressive I kappa B-alpha only marginally
impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM ( a specific p38/SAPK2 inhibitor ) led to reduced IL-10 expression
Kis et al., Blood 2006
(Burkitt Lymphoma...) :
IL-10 can
induce the expression of EBV encoded
latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma derived cell lines ... We show now that both human and EBV encoded
IL-10 can
induce LMP-1 in the absence of EBNA-2 in the Daudi, P3HR1, and other BL cell lines ...
IL-10 could also
induce LMP-1 in the conditional lymphoblastoid cell line ER/EB2-5 where EBNA-2 was downregulated in the absence of estrogen ... Moreover,
IL-10 could induce the expression of LMP-1 in tonsillar B cells infected with the nontransforming, EBNA-2-deficient EBV strain P3HR1 and
enhance LMP-1 expression in 2 EBV positive NK lymphoma lines ... The demonstration that
IL-10 can
induce the expression of
LMP-1 in an EBNA-2 independent manner shows that the major transforming EBV gene LMP-1 can be induced by extracellular signals in lymphoid cells, and IL-10 might contribute to the establishment of type II EBV latency
Kis et al., Immunol Lett 2006
(Hodgkin Disease) :
IL-10 induced
LMP-1 also in tonsillar B-cells infected with the EBNA-2 deleted virus strain P3HR-1
Lambert et al., J Immunol 2007
:
However, the mechanisms by which
LMP1 induces
IL-10 are incompletely understood ... To test the hypothesis that PI3K, which acts upstream of mammalian target of rapamycin, might also be involved in
LMP1 dependent
IL-10 production, we generated B cell lines expressing signaling-inducible chimeric LMP1 ... We find that GSK3beta regulates
LMP1 dependent
IL-10 induction, with GSK3beta inhibition by pharmacologic or small interfering RNA strategies enhancing LMP1 induced IL-10 induction
Lin et al., Cytokine 2010
:
Here we have identified an important signaling event mediated by a dsRNA dependent serine/threonine protein kinase, PKR, in regulating
LMP1 induced IL-6 and
IL-10 expression
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that
NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and
induce IL-10 production
Nakagomi et al., Int J Cancer 1994
(Burkitt Lymphoma) :
The Epstein-Barr virus
latent membrane protein-1 (LMP1) induces
interleukin-10 production in Burkitt lymphoma lines