Chabaud-Riou et al., Am J Pathol 2004
(Arthritis, Rheumatoid...) :
Phospho-MKK3 levels were low in medium treated FLS, but were rapidly increased by interleukin-1 and tumor necrosis factor-alpha , although phospho-MKK6 levels only modestly increased
Shukla et al., Carcinogenesis 2011
:
The non-IKK-phosphorylable p65-S534A mutant did not induce HBx protein stability ; hence, phosphorylation of p65 by IKK is a key step in TNF-a induced stabilization of HBx. Phospho-p65 showed higher affinity to HBx compared with the non-phosphorylable p65 mutant, suggesting that the interaction of phospho-p65 with HBx might be important for HBx stabilization