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HMOX1 — PIK3R1
Text-mined interactions from Literome
Salinas et al., J Biol Chem 2003
:
In this study, we demonstrate that nerve growth factor (NGF) prevents the accumulation of ROS in dopaminergic PC12 cells challenged with the Parkinson 's disease related neurotoxin 6-hydroxydopamine ( 6-OHDA ) by a mechanism that involves
PI3K/Akt dependent
induction of the stress response protein
heme oxygenase-1 (HO-1)
Martin et al., J Biol Chem 2004
:
Inhibition of
PI3K reduced the increase in Nrf2 protein levels and activation of the
ho1 promoter
Pischke et al., Cell Mol Biol Incl Cyto Enzymol 2005
(Inflammation) :
Since activation of heme oxygenase-1 and PI3K/Akt both protect the cellular environment, we postulated that
PI3K/Akt can
regulate the induction of
heme oxygenase-1 by proinflammatory stress
Brunt et al., Arterioscler Thromb Vasc Biol 2006
:
Inhibition of
PI3K-Akt reduced induction of
HO-1 protein expression by H2O2 and blocked its anti-apoptotic effects
Zhang et al., Am J Respir Cell Mol Biol 2008
(MAP Kinase Signaling System) :
Acrolein
induces heme oxygenase-1 through PKC-delta and
PI3K in human bronchial epithelial cells
Zhang et al., Free radical research 2008
:
Protection of chlorophyllin against oxidative damage by inducing
HO-1 and NQO1 expression
mediated by
PI3K/Akt and Nrf2 ... In conclusion, this study proved that CHL exerts antioxidant effect by inducing
HO-1 and NQO1 expression
mediated by
PI3K/Akt and Nrf2
Hwang et al., Toxicol Appl Pharmacol 2008
:
Also, puerarin mediated increases in
PI3K activation and
HO-1 induction were reversed by co-treatment with ICI 182,780 and pertussis toxin
Park et al., Biochem Biophys Res Commun 2009
:
HO-1 expression by PGE ( 2 ) was
inhibited by LY294002,
PI3K inhibitor and H89, PKA inhibitor ... Taken together, we conclude that PGE ( 2 )
induces HO-1 protein expression through PKA and
PI3K signaling pathways via EP ( 2 ) receptor in C6 cells
Hwang et al., Toxicol Appl Pharmacol 2010
:
Also, Rb1 mediated increases in
PI3K activation and
HO-1 induction were reversed by co-treatment with ICI 182,780 and pertussis toxin
Genc et al., Cell Biochem Funct 2010
:
These results suggest that Epo
induces neural
HO-1 expression through the activation of
PI3K , MAPK, and Nrf2 pathways, and this may unveil a novel mechanism which mediates the cytoprotective responses elicited by Epo
Romero et al., J Pineal Res 2010
(Neuroblastoma) :
The neuroprotective effect was prevented by chelerythrine, LY294002, and Sn ( IV ) protoporphyrin IX dichloride ( SnPP ), indicating the participation of the
PKC/PI3K/Akt activation and
induction of the antioxidant enzyme
heme oxygenase-1
Hinkelmann et al., Eur J Pharm Sci 2010
:
The increased
HO-1 mRNA stability by this compound was
blocked by inhibition of
PI3K/Akt , but not by that of p38 MAPK
Feng et al., J Cell Biochem 2011
:
PI3K and ERK/Nrf2 pathways are
involved in oleanolic acid induced
heme oxygenase-1 expression in rat vascular smooth muscle cells
Ke et al., J Hepatol 2012
(Disease Models, Animal...) :
These findings underscore the
role of
HO-1 induced STAT3 in modulating
PI3K/PTEN in liver IRI cascade
Park et al., Int Immunopharmacol 2011
:
Schisandra chinensis a-iso-cubebenol
induces heme oxygenase-1 expression through
PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide stimulated macrophages
Lee et al., Food Chem Toxicol 2012
(Mesothelioma) :
Reactive oxygen species and
PI3K/Akt signaling
play key roles in the induction of Nrf2-driven
heme oxygenase-1 expression in sulforaphane treated human mesothelioma MSTO-211H cells ... Overall, our results indicate that ROS generation and/or activation of
PI3K/Akt signaling
regulate cell survival and Nrf2-driven
HO-1 expression in sulforaphane treated MSTO-211H cells
Hsu et al., Eur J Pharm Sci 2012
:
BBR ( 0.1-10 nM ) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive
Nrf2/HO-1 induction, which were
blocked by a
PI3K inhibitor, LY294002
Dal-Cim et al., Neurochem Int 2012
(Neuroblastoma) :
In conclusion, our results show that guanosine can afford protection against mitochondrial oxidative stress by a signaling pathway that implicates
PI3K/Akt/GSK-3ß proteins and
induction of the antioxidant enzyme
HO-1
Tsai et al., Cellular oncology (Dordrecht) 2012
(Carcinoma, Non-Small-Cell Lung...) :
In addition, we found that
HO-1 expression can be
inhibited by
PI3K and AKT inhibitors, but not by MAPK inhibitors
Li et al., Marine drugs 2013
:
Furthermore,
PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126
suppressed the induction of
HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not
Yang et al., Oxidative medicine and cellular longevity 2013
:
In conclusion, these results suggest that SPD induces
PI3K/Akt-Nrf2 mediated
HO-1 expression in human endothelial cells, which may have a role in cytoprotection of the cells against oxidative stress induced death