Kim et al., Biochem Biophys Res Commun 2008
(Breast Neoplasms) :
Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells ... We found that Pin1 increases the transcriptional activity and protein level of vascular endothelial growth factor ( VEGF ) in the human breast cancer cell line, MCF-7
Kim et al., Food Chem Toxicol 2012
(Breast Neoplasms...) :
We have previously reported that TAM-resistant MCF-7 ( TAMR-MCF-7 ) cells have elevated angiogenic potential via Pin1 dependent vascular endothelial growth factor ( VEGF ) production ... These results demonstrate for the first time that amurensin G may have therapeutic potential for TAM-resistant breast cancer through blocking of Pin1 mediated VEGF gene transcription
Lv et al., J Cell Mol Med 2013
:
In addition, VEGF expression was stimulated by Pin1 , which unveiled part of the mechanism of Pin1 in regulating VSMC migration in T2D