Gene interactions and pathways from curated databases and text-mining

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INS — PIP

Text-mined interactions from Literome

Keeton et al., Endocrinology 2005 (Carcinoma, Hepatocellular...) : We report that : 1 ) insulin induced transcription of ATF-3, Pip92 , and Insig-1 required MEK-ERK activation ; 2 ) insulin induced transcription of ATF-3 and Pip92 reached maximum levels within 15 min and was blocked by wortmannin but not LY294002 ; 3 ) in contrast, the maximum level of insulin induced transcription of Insig-1 was delayed and was not blocked by either wortmannin or LY294002 ; 4 ) insulin activated ERK1/2 in two distinct phases, a rapid peak and a later plateau ; 5 ) the delayed plateau phase of insulin induced ERK1/2 activation was partially phosphatidylinositol 3-OH-kinase dependent ; and 6 ) however, the rapid, insulin induced peak of ERK1/2 activation was blocked by wortmannin but not LY294002
Lanzafame et al., Am J Physiol Heart Circ Physiol 2006 (Reperfusion Injury) : The increased PIP2 in the caveolar fractions where signaling proteins are concentrated may be critical for the heightened generation of Ins ( 1,4,5 ) P3 in early reperfusion
Tengholm et al., Vitam Horm 2009 : This review summarises the mechanisms involved in formation and degradation of PIP ( 3 ) in insulin-responsive cells, how PIP ( 3 ) can be measured in individual cells as well as accumulating evidence that the plasma membrane PIP ( 3 ) concentration undergoes complex spatio-temporal patterns in many types of cells, with particular emphasis on autocrine insulin induced PIP ( 3 ) oscillations in pancreatic beta-cells
Farese et al., Biochem J 1985 : We have previously reported that insulin increases the synthesis de novo of phosphatidic acid ( PA ), phosphatidylinositol ( PI ), phosphatidylinositol 4-phosphate (PIP) , phosphatidylinositol 4,5-bisphosphate ( PIP2 ) and diacylglycerol ( DAG ) in BC3H-1 myocytes and/or rat adipose tissue
Wasner et al., Acta Diabetol 1993 : The synthesis of cyclic PIP is stimulated by insulin or noradrenaline ( alpha-adrenergic action ) in a dose dependent fashion