Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Edelstein , Clin J Am Soc Nephrol 2008 (Polycystic Kidney, Autosomal Recessive) : This review focuses on mammalian target of rapamycin and apoptosis signaling pathways in polycystic kidney disease and the role of mammalian target of rapamycin inhibitors and apoptosis inhibitors as potential therapies to reduce cyst formation
Lieberthal et al., J Am Soc Nephrol 2009 (Carcinoma, Renal Cell...) : mTOR also plays an important role in mediating cyst formation and enlargement in autosomal dominant polycystic kidney disease
Huber et al., Kidney Int 2011 (Diabetic Nephropathies...) : Polycystin 1 regulates mTOR activity through different pathways, and TSC intersects with the primary cilium, a crucial cell organelle in the pathogenesis of PKD