Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PPARA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gardner et al., J Biol Chem 2003 (MAP Kinase Signaling System) : However, the mechanism for PPAR ligand dependent MAPK activation is unclear
Aouadi et al., Diabetes 2006 : Finally, either inhibition or disruption of p38MAPK increased peroxisome proliferator activated receptor ( PPAR)gamma expression and transactivation
Ding et al., Acta Pharmacol Sin 2007 : Taken together, these results showed a close association between PPAR alpha and cardiomyocyte differentiation in vitro, and p38 MAPK was partly responsible for the regulation of PPAR alpha
Diradourian et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK ... In this study we examined the effect of p38-MAPK on PPARalpha transcriptional activity
Martínez de Ubago et al., Biochim Biophys Acta 2009 (Carcinoma, Hepatocellular...) : Activation of PPAR-alpha by the pharmacological agonist WY14643 in HTC hepatoma cells is sufficient to inhibit insulin signalling and this effect is also dependent on p38 MAPK but not JNK kinase ... In summary, OEA inhibits insulin metabolic and mitogenic signalling by activation of JNK and p38 MAPK via PPAR-alpha
Yang et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System...) : Specific inhibitors of the mitogen activated protein kinases ( MAPK ) p38 ( SB203580 ) and c-Jun N-terminal kinase ( SP600125 ), but not of extracellular signal regulated kinase ( PD98059 ), prevented AGEs induced downregulation of PPAR? expression
Wang et al., PPAR research 2012 : Leptin treatment also leads to a mild downregulation of PPAR mRNA expression and a significant MAPK/ERK dependent PPAR? phosphorylation at serine 112/82
Liu et al., Biomaterials 2013 (Brain Ischemia) : Furthermore, CBSA-PEG-TIIA-NPs significantly decreased the mRNA expressions of iNOS and p38MAPK, upregulated PPAR? expression, and inhibited the protein levels of iNOS, GFAP and p38MAPK phosphorylation