Gene interactions and pathways from curated databases and text-mining

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ARG1 — PRKAA2

Text-mined interactions from Literome

Łabuzek et al., Neurotoxicology 2010 : The presented evidence supports the conclusion that AMPK activated by AICAR is involved in regulation of ROS and cytokine production ( IL-1 beta, TNF-alpha ( 6h ), IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010 (Inflammation) : However, compound C down-regulated IL-1 beta, IL-6 and TNF alpha release, NO, ROS production, and AMPK activity, diminished NF-kappaB and HIF-1 alpha expression, as well as increased arginase I expression in lipopolysaccharide (LPS) stimulated microglia
Łabuzek et al., Pharmacol Rep 2010 : Furthermore, the effects of metformin on the release of IL-1ß, IL-6, IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I , iNOS, NF-?B p65 and PGC-1a were not AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin
de Castro Barbosa et al., Metabolism 2013 : Arg-treatment increased : 1 ) basal and insulin stimulated glycogen synthesis ; 2 ) glucose uptake ; 3 ) palmitate oxidation ; 4 ) p-Akt ( Ser ( 473 ) ), total and plasma membrane GLUT4 content, total and p-AMPK-a and p-ACC ( Ser ( 79 ) ), p-GSK-3a/ß ( Ser ( 21/9 ) ) and 5 ) nitrite and c-GMP levels