◀ Back to IL2

IL2 — PRKAA2

Text-mined interactions from Literome

Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Jhun et al., Biochem Biophys Res Commun 2006 : In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells ... Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin ( PMA/Io ) or with monoclonal anti-CD3 plus anti-CD28 ... We then showed that AMPK inhibition reduced PMA/Io induced IL-2 mRNA expression and IL-2 promoter activation ... These results suggest that AMPK mediates IL-2 production by regulating NF-AT and AP-1activation during T cell stimulation