Gene interactions and pathways from curated databases and text-mining

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MAPK8 — PRKACG

Text-mined interactions from Literome

Nishizaki et al., Brain Res Mol Brain Res 1999 (Ion Channel Gating) : In contrast, the protein synthesis inhibitor, cycloheximide, the selective inhibitor of cAMP dependent protein kinase (PKA) , H-89, the selective inhibitors of protein kinase C ( PKC ), PKCI and GF109203X, the mitogen activated protein ( MAP ) kinase kinase inhibitor , PD98059, or the inactive CaMKII inhibitors, KN-92 and NP218, had no effect on the currents
Xing et al., J Biol Chem 1999 : Taken together, these results indicate that negative feedback regulation via cAMP/PKA mediated inhibition of mitogen activated protein kinase occurs for some, but not all, classes of receptors that promote PLA2 activation and AA release
Han et al., Endocrinology 1999 : The results show that MAPK can be activated in a PKA dependent manner in GGH ( 3 ) 1 ' cells
Roberson et al., J Neurosci 1999 : In the present studies we observed that hippocampal MAPK activation is regulated by both the PKA and PKC systems ; moreover, we found that a wide variety of neuromodulatory neurotransmitter receptors ( metabotropic glutamate receptors, muscarinic acetylcholine receptors, dopamine receptors, and beta-adrenergic receptors ) couple to MAPK activation via these two cascades
Zhang et al., J Neurochem 1999 (Glioma...) : Taken together, our results provide the first evidence for coupling of DOR and ORL1 to the p38 MAPK cascade and clearly demonstrate that receptor mediated activation of p38 MAPK both involves PKA and is negatively regulated by PKC
Zheng et al., J Biol Chem 2000 : In contrast, a specific peptide inhibitor of PKA, PKI ( 5 microm ), completely abolished the stimulatory effect of beta ( 2 ) -AR, suggesting that beta ( 2 ) -AR induced p38 MAPK activation is mediated via a PKA dependent mechanism, rather than by G ( i ) or Gbetagamma
Cao et al., J Biol Chem 2001 : The involvement of PKA in beta ( 3 ) AR-dependent p38 MAPK activation was confirmed by the ability of the PKA inhibitors H89 ( 20 microm ) and ( R ( p ) ) -cAMP-S ( 1 mm ) to block phosphorylation of p38 MAPK
Nakamura et al., J Am Soc Nephrol 2001 : However, inhibition of MAPK ( p42/p44 ) and TNF-alpha promoter activity was partially prevented by the cAMP-protein kinase (PKA) inhibitors, H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ), whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors
Deeble et al., Mol Cell Biol 2001 (MAP Kinase Signaling System...) : Convergent IL-6 and PKA signaling also resulted in potentiated mitogen activated protein kinase ( MAPK ) activation without affecting the level of signal transducer and activator of transcription or PKA activation observed with these agents alone
Swarthout et al., Gene 2002 : However, while PKA is linked to many of the changes in gene expression directed by PTH, PKA activation has been shown to inhibit mitogen activated protein kinase ( MAPK ) and proliferation of osteoblasts
Kim et al., Biochem Biophys Res Commun 2002 (Neuroblastoma) : Interestingly, KT5720, a specific inhibitor of PKA , markedly suppressed the phosphorylation of MAPK by N/OFQ in SH-SY5Y cells
Lau et al., Br J Haematol 2002 (MAP Kinase Signaling System) : Activation of protein kinase A (PKA) , however, lowered PAI-1 secretion induced by uPA and tPA, as a result of an inhibition of the PKC pathway and inhibition of Raf, Mek and MAPK phosphorylations
Salvador et al., Endocrinology 2002 : The PKA inhibitor H89 as well as the myristoylated PKA inhibitor peptide PKI strongly inhibited hCG stimulated p42/44 MAPK phosphorylation, whereas the PKC inhibitor GF109203X had no effect on p42/44 MAPK phosphorylation ... Taken together, these results indicate that, under primary culture conditions where physiological levels of signaling proteins are present, hCG signals to activate MEK, p42/44 MAPK , CREB, and histone H3 in a predominantly PKA dependent and PKC independent manner
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Leong et al., Mol Endocrinol 2004 (Adenocarcinoma...) : DIM stimulated MAPK activity and induced phosphorylation of the endogenous PKA target, cAMP response element binding protein ( CREB ), in a PKA dependent manner
Chio et al., Cell Signal 2004 : PKA dependent activation of PKC, p38 MAPK and IKK in macrophage : implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP
Tsai et al., Endocrinology 2004 : PKA is required for protection and was prevented by H89 ( a PKA inhibitor ), but not PD98059 ( a MAPK kinase inhibitor )
Hu et al., Neuron 2004 (MAP Kinase Signaling System) : Inhibiting PKA during 5-HT applications and inhibiting receptor tyrosine kinase or MAPK during sensorin application blocked both LTF and MAPK activation and translocation
Kobayashi et al., J Biol Chem 2005 : RANKL induced degradation of I kappa B alpha and phosphorylation of p38 MAPK and c-Jun N-terminal kinase in RAW264.7 cells were up-regulated by PGE2 in a cAMP dependent protein kinase A (PKA) dependent manner, suggesting that EP2 and EP4 signals cross-talk with RANK signals
Hildesheim et al., J Biol Chem 2005 (Adenomatous Polyposis Coli...) : Moreover, lack of normal p38 MAPK activity in either Gadd45a-null keratinocytes or in p38 MAPK inhibitor treated keratinocytes leads to decreased CK2 activity and increased PKA activity
Pasapera et al., J Steroid Biochem Mol Biol 2005 : Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked ( approximately 90 % ) by H89 ( PKA inhibitor ) and LY294002 but not by Wortmannin ( PI3-K inhibitors ), 4-OH-tamoxifen, ICI182,780 or SB203580 ( p38 MAPK inhibitor ) ; PD98059 ( ERK1/2 inhibitor ) partially ( approximately 30 % ) blocked the FSH mediated effect
Zhang et al., Endocrinology 2006 : ERK MAPK was also induced by the heat treatment in a time- and protein kinase A (PKA) dependent manner
Calebiro et al., Mol Endocrinol 2006 : The inhibitory effect of PKA I apparently required constitutive MAPK activation and was associated with an inhibition of ERK phosphorylation
Tang et al., Cell Signal 2008 : ERK ( 1/2 ) activation involves Gq/phospholipase C (PLC)/protein kinase C ( PKC ), Gs/adenylyl cyclase ( AC ) /cAMP/protein kinase A (PKA) and Gi cascades ; however, the Gq/PLC/PKC pathway, as well as PKA is not required for OX2R mediated p38 MAPK activation
Evaul et al., J Biol Chem 2008 (MAP Kinase Signaling System) : LH-induced increases in cAMP and cAMP dependent protein kinase (PKA) activity mediated trans-activation of the EGF receptor and subsequent mitogen activated protein kinase ( MAPK ) activation, ultimately leading to StAR phosphorylation and mitochondrial translocation
Rosenkranz et al., J Physiol 2009 : Both forms of plasticity are blocked by inhibition of PKA and occluded by interfering with cAMP degradation, consistent with a PKA mediated increase in MAPK activity following induction of LTP
McAlees et al., Mol Cell Biol 2009 : beta ( 2 ) AR agonists, cAMP elevating agents, and PKA inhibitors were used to show that beta ( 2 ) AR stimulation resulted in a PKA dependent increase in p38 MAPK phosphorylation
Chaves et al., Mech Ageing Dev 2009 : The inhibitory effect of IL-10 on 20-49 years old group was reversed by the pre-treatment with H89 ( PKA inhibitor ) but not with PD169316 ( p38 MAPK inhibitor )
Liu et al., J Mol Neurosci 2011 : To further understand the anti-inflammatory effect of adenosine cyclic 3',5'-monophosphate ( cAMP ), we examined the effect of protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor ( Epac ) on the transcription and production of cytokines and on the activity of mitogen activated protein kinases ( MAPK ) p38 and glycogen synthase kinase-3ß ( GSK-3ß ) in endotoxin treated rat primary cultured microglia
Makarevich et al., Horm Metab Res 2010 : A PKA inhibitor, KT 5720 suppressed the expression of PKA and MAPK/ERK1,2 , the IGF-I release, and the ratio of PCNA positive cells in granulosa cells ... These observations confirm the involvement of PKs in control of basic ovarian functions and demonstrate the involvement of PKA in stimulation of ovarian cell proliferation and MAPK ( but not CDK ) and in promotion of ovarian IGF-I release
Lajevic et al., Immunology 2011 (Thymoma) : p38 MAPK activation involves the ßAR, Gs protein, AC, cAMP and PKA , as determined through the use of a ßAR antagonist, activators of AC and cAMP, and S49 clonal mutants deficient in Gs and PKA
Begum et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB mediated induction of p21, leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression
Guo et al., Chin Med J (Engl) 2010 (Fibrosis...) : The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation, and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and CTGF expression were detected by immunoblotting assay ... A PKA activator as well as PKC activators induced MAPK phosphorylation, and both PKA and PKC inhibitors antagonized PTH induced MAPK phosphorylation and CTGF expression
Michel et al., J Neurosci 2012 : Using Western blotting, we found that sustained MAPK phosphorylation was dependent upon protein synthesis, but not PKA or PKC activity
Khan et al., Gen Comp Endocrinol 2013 : In addition, inhibition of endogenous PKA by a more selective peptide inhibitor [ PKI- ( 6-22 ) -amide ] was sufficient to resume GVBD and MAPK activation in intact perch oocytes
Shan et al., J Gastroenterol Hepatol 2013 : Inhibition of PKA did not block the bile acid induced p38 MAPK activation
Graves et al., Proc Natl Acad Sci U S A 1993 : PKA did not inhibit MAPKK and MAPK activity in vitro, and MAPKK and MAPK from extracts of forskolin treated cells could be activated normally with purified Raf-1 and MAPKK, respectively, suggesting that PKA blocked signaling upstream of MAPKK
VanRenterghem et al., J Biol Chem 1994 : Furthermore, inhibition of endogenous PKA by the heat-stable PKA inhibitor is sufficient to stimulate MAPK activity in these extracts in the absence of protein synthesis and without dependence on a functional Ras protein
Bornfeldt et al., J Clin Invest 1997 : In these cells, PDGF induced MAPK activation leads to cytosolic phospholipase A2 activation, PGE2 release, and subsequent activation of the cAMP dependent protein kinase (PKA) , which acts as a strong inhibitor of SMC proliferation
Maizels et al., Endocrinology 1998 : FSH induced phosphorylation of p38 MAPK was blocked by pretreatment with the protein kinase A (PKA) inhibitor H89 and mimicked by the cAMP generating agonist forskolin, indicating that FSH induced cAMP production and PKA activation are necessary and sufficient for the activation of p38 MAPK in GC
Agati et al., J Biol Chem 1998 : Thus, insulin inhibition of PKA induced PEPCK expression does not require MAPK activation but does require activation of PI3-kinase, although this signal is not transmitted through the PKB or PKC pathways