Gene interactions and pathways from curated databases and text-mining

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PRKAG2 — TNFSF11

Text-mined interactions from Literome

Lee et al., Bone 2010 (Bone Resorption) : STO-609, an inhibitor of CaMKK, completely blocked the RANKL induced activation of AMPK-a , but KN-93, an inhibitor of CaMK, did not ... siRNA mediated TAK1 knockdown also blocked RANKL induced activation of AMPK-a ... AMPK negatively regulates RANKL , possibly by acting through CaMKK and TAK1
Feng et al., Chin Med J (Engl) 2012 : The effect of AMPK activation on RANKL expression in hPDL cells was investigated by real-time PCR and Western blotting ... Suppression of AMPK by Compound C augmented RANKL expression, and AMPK activation by metformin significantly decreased RANKL expression in hPDL cells ... High glucose induced up-regulation of RANKL could be due to decreased AMPK activity, and AMPK activation may be involved in regulating of RANKL expression in hPDL cells