Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — PRKAR2A

Text-mined interactions from Literome

Jiang et al., Proc Natl Acad Sci U S A 2001 : We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by PKA and that an increase in intracellular calcium concentration is required for maximal ERK activation
Duca et al., Mol Pharmacol 2005 : The simultaneous inhibition of PKA and PI3K, by N- ( 2- ( p-bromocinnamylamino ) ethyl ) -5-isoquinolinesulfonamide ( H89 ) and 2- ( 4-morpholynil ) -8-phenyl-4H-1-bemzopyran-4-one ( LY294002 ), respectively, blocked MEK1/2 and ERK1/2 phosphorylation, as did lactose, an EBP antagonist
Keeley et al., Biotechniques 2005 (MAP Kinase Signaling System) : The novel hybrid transcription factor TetR-Elk-1 was regulated by MAPK ERK kinase 1 (MEK-1) overexpression, and TetR-CREB was regulated by protein kinase A (PKA) overexpression or elevation of cyclic AMP levels