Gene interactions and pathways from curated databases and text-mining

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MAPK1 — PRKCA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Braz et al., J Cell Biol 2002 (Cardiomyopathy, Hypertrophic) : A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal regulated kinase1/2 ( ERK1/2 ), that dominant negative PKC alpha inhibited PMA induced ERK1/2 activation, and that dominant negative MEK1 ( up-stream of ERK1/2 ) inhibited wild-type PKC alpha induced hypertrophic growth
Lampasso et al., J Bone Miner Res 2002 : The specific inhibition of PKCalpha by antisense ODNs resulted in inhibition of MAPK activity leading to a significant decrease in proliferation
Nakajima et al., Neurochem Int 2004 : In addition, the PKC alpha levels in the LPS stimulated microglia were observed to decrease in response to the p38MAPK inhibitor, indicating that the PKC alpha levels are regulated by the p38MAPK activity
Lehoux et al., Mol Cell Endocrinol 2007 (MAP Kinase Signaling System) : Using pharmaceutical and overexpression approaches we have previously reported that in H295R cells, ( a ) angiotensin II ( AII ) activates PKCepsilon, PKCalpha and p44/42 MAPK pathway, ( b ) PKCepsilon, PKCalpha and p44/42 MAPK overexpression inhibits AII induced CYP11B2 gene transcription and ( c ) overexpression of PKCepsilon inhibits CYP11B2 gene transcription through p44/42 MAPK activation [ LeHoux, J.G., Dupuis, G., Lefebvre, A., 2001 ... The aim of the present work was to evaluate the physiological role of endogenous PKCepsilon and PKCalpha isoforms in the activation of p44/42 MAPK by AII
Zheng et al., Neuroscience 2008 (Synaptic Transmission) : Analysis of protein expression revealed that PKCzeta is activated in early stages of conditioning followed shortly afterward by increased levels of PKCalpha/beta and activation of ERK MAPK
Kim et al., J Biol Chem 2009 : In summary, PKCalpha , which was activated in senescent cells by ROS strongly activated Erk1/2 , and the SA-pErk1/2 in turn phosphorylated Sp1 on Ser ( 59 )
Hardy et al., Immunology 2009 : However, PKC-alpha phosphorylation was independent of PI3K and p38 MAPK , indicating that IFN-gamma induced phosphorylation and nuclear translocation of PKC-alpha are mediated by distinct mechanisms ... Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Debata et al., Biochem Biophys Res Commun 2010 : Erk1/2 dependent phosphorylation of PKCalpha at threonine 638 in hippocampal 5-HT(1A) receptor mediated signaling
Haneda et al., J Diabetes Complications 1995 : These results indicate that the translocation of PKC alpha and zeta and the activation of MAPK under high glucose conditions might be underlying mechanisms of the functional disturbance of mesangial cells in diabetes
Yu et al., Mol Pharmacol 1996 : These results demonstrate that ATP induced Raf-1 and MAPK activations involve the activation of PKC-alpha and PKC-delta
Hoshino et al., J Biol Chem 1998 (Leukemia, Myeloid) : Thus, LTD4 has at least two distinct signaling pathways in THP-1 cells, a PTX-insensitive mitogen activated protein kinase activation through protein kinase Calpha and Raf-1 and a PTX-sensitive chemotactic response
Husain et al., Biochim Biophys Acta 1998 : The data presented are consistent with a role for PKCalpha , but not for p42/p44 mitogen activated protein kinase ( MAPK ), in cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells