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EGFR — PRKDC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dittmann et al., J Biol Chem 2005
:
Blockade of EGFR import by the anti-EGFR monoclonal antibody C225 abolished
EGFR import into the nucleus and radiation induced
activation of
DNA-PK , inhibited DNA repair, and increased radiosensitivity of treated cells
Dittmann et al., Radiother Oncol 2005
:
Inhibition of radiation induced
EGFR nuclear import by C225 ( Cetuximab )
suppresses DNA-PK activity
Friedmann et al., Mol Cancer Ther 2006
(Neoplasms) :
In this study, we specifically investigated the
effect of
EGFR inhibition by gefitinib on functional activity of DNA-PK in cancer cell lines and the interaction between EGFR and
DNA-PK
Wanner et al., Radiother Oncol 2008
:
Nuclear
EGFR is
involved in phosphorylation of
DNA-PK at Thr2609, which has a significant impact upon DNA-DSB repair
Dittmann et al., Molecular cancer 2008
:
Radiation induced caveolin-1 associated EGFR internalization is linked with nuclear
EGFR transport and
activation of
DNA-PK ... Radiation induced caveolin-1- and EGFR-phosphorylations were associated with nuclear
EGFR transport and
activation of
DNA-PK , as detected by phosphorylation at T2609
Minjgee et al., Int J Radiat Oncol Biol Phys 2011
:
K-RAS ( V12 ) induces autocrine production of EGFR ligands and mediates radioresistance through
EGFR dependent Akt signaling and
activation of
DNA-PKcs
Bandyopadhyay et al., J Biol Chem 1998
:
Anti-EGFR mAb induced physical interaction between EGFR and
DNA-PK or Ku70/80 was
dependent on the presence of EGFR, but not on the levels of
EGFR ... Our findings demonstrate the existence of a novel cellular pathway in mammalian cells that involves physical interactions between EGFR and
DNA-PK or Ku70/80 in
response to inhibition of
EGFR signaling