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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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EGFR — PRKDC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Bandyopadhyay et al., J Biol Chem 1998 : Anti-EGFR mAb induced physical interaction between EGFR and DNA-PK or Ku70/80 was dependent on the presence of EGFR, but not on the levels of EGFR ... Our findings demonstrate the existence of a novel cellular pathway in mammalian cells that involves physical interactions between EGFR and DNA-PK or Ku70/80 in response to inhibition of EGFR signaling
Dittmann et al., J Biol Chem 2005 : Blockade of EGFR import by the anti-EGFR monoclonal antibody C225 abolished EGFR import into the nucleus and radiation induced activation of DNA-PK , inhibited DNA repair, and increased radiosensitivity of treated cells
Dittmann et al., Radiother Oncol 2005 : Inhibition of radiation induced EGFR nuclear import by C225 ( Cetuximab ) suppresses DNA-PK activity
Friedmann et al., Mol Cancer Ther 2006 (Neoplasms) : In this study, we specifically investigated the effect of EGFR inhibition by gefitinib on functional activity of DNA-PK in cancer cell lines and the interaction between EGFR and DNA-PK
Dittmann et al., Molecular cancer 2008 : Radiation induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK ... Radiation induced caveolin-1- and EGFR-phosphorylations were associated with nuclear EGFR transport and activation of DNA-PK , as detected by phosphorylation at T2609
Minjgee et al., Int J Radiat Oncol Biol Phys 2011 : K-RAS ( V12 ) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR dependent Akt signaling and activation of DNA-PKcs
Wanner et al., Radiother Oncol 2008 : Nuclear EGFR is involved in phosphorylation of DNA-PK at Thr2609, which has a significant impact upon DNA-DSB repair