Gene interactions and pathways from curated databases and text-mining

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PRNP — TP53

Text-mined interactions from Literome

Hafiz et al., Mol Cell Neurosci 2000 (Gliosis...) : PrP106-126 induces increased progression through the cell cycle to late G1 and enhances the level of both p53 and phosphorylated ERKs in astrocytes
Vincent et al., J Neurosci 2009 : We demonstrate that AICD dependent control of PrP ( c ) involves the tumor suppressor p53
Seo et al., Neurobiol Aging 2012 : Resveratrol mediated SIRT1 activation decreased the acetylation of p53 and p65 induced by prion protein and SIRT1 inhibitor