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PSMD1 — TOP1

Text-mined interactions from Literome

Mao et al., Proc Natl Acad Sci U S A 2000 : Ubiquitin/26S proteasome dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1 mediated DNA damage
Desai et al., Cancer Res 2001 (Breast Neoplasms...) : Ubiquitin/26S proteasome mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
Li et al., Cancer Res 2003 (Colonic Neoplasms...) : Indeed, ARC-111, like CPT, was shown to induce reversible TOP1 cleavage complexes in tumor cells as evidenced by specific reduction of the TOP1 immunoreactive band in a band depletion assay, as well as elevation of small ubiquitin modifier-TOP1 conjugate levels and activation of 26S proteasome mediated degradation of TOP1