Tang et al., Cancer Res 2001
:
Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes ... We examined whether Akt and glycogen synthase kinase 3beta ( GSK-3beta ), components of the phosphatidylinositol 3'-kinase pathway, are involved in UVB induction of COX-2 transcription ... Inhibition of GSK-3beta by lithium induced endogenous COX-2 protein expression and COX-2 promoter activity ... Finally, overexpression of a dominant negative Akt mutant or wild-type GSK-3beta suppressed UVB mediated induction of COX-2 promoter
Thiel et al., J Biol Chem 2006
(Stomach Neoplasms) :
Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells ... Our data show that inhibition of GSK-3beta stimulates COX-2 expression in gastric cancer cells, which seems to be primarily facilitated via an increase in mRNA stability and to a lesser extent through enhanced transcription