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PTH1R — PTHLH

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTH1R → PTHLH (directlyIncreases, PTHLH Activity) Mahon et al., Nature 2002*
  Evidence: The parathyroid hormone 1 receptor (PTH1R) is a class II G-protein-coupled receptor. PTH1R agonists include both PTH, a hormone that regulates blood calcium and phosphate, and PTH-related protein (PTHrP)
• Reactome Reaction: PTHLH → PTH1R (direct_complex) Hansen et al., J Endocrinol 2002*, Della Penna et al., Neuropharmacology 2003*, Suva et al., Science 1987*, Hendy et al., Proc Natl Acad Sci U S A 1981*, Usdin et al., J Biol Chem 1995*, Schneider et al., FEBS Lett 1994*, Schipani et al., Endocrinology 1993*, Schneider et al., Eur J Pharmacol 1993*, Offermanns et al., Mol Endocrinol 1996*, Behar et al., Endocrinology 1996*
• Reactome Reaction: PTHLH → PTH1R (reaction) Hansen et al., J Endocrinol 2002*, Wenzel-Seifert et al., Biochem Pharmacol 2002, Della Penna et al., Neuropharmacology 2003*, Zhang et al., Eur J Pharmacol 2003, Lambert et al., Science signaling 2008, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Suva et al., Science 1987*, Hendy et al., Proc Natl Acad Sci U S A 1981*, Usdin et al., J Biol Chem 1995*, Schneider et al., FEBS Lett 1994*, Schipani et al., Endocrinology 1993*, Schneider et al., Eur J Pharmacol 1993*, Offermanns et al., Mol Endocrinol 1996*, Behar et al., Endocrinology 1996*, Baker et al., J Biol Chem 1998
• WikiPathways Endochondral Ossification: PTHLH → PTH1R (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTHLH — PTH1R (direct interaction, pull down) Zhou et al., Proc Natl Acad Sci U S A 1997*
• IRef Hprd Interaction: PTHLH — PTH1R (in vivo) Zhou et al., Proc Natl Acad Sci U S A 1997*
• IRef Ophid Interaction: PTHLH — PTH1R (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Errazahi et al., J Steroid Biochem Mol Biol 2004 : PTH-1R responses to PTHrP and regulation by vitamin D in keratinocytes and adjacent fibroblasts
Song et al., Mol Endocrinol 2009 : In this study, we investigated the regulation of PTH1R expression by endogenous PTHrP and the associated effects on VSMC proliferation ... Blocking binding of secreted PTHrP fragments to the PTH1R by treatment with either an antagonist or an antibody against PTHrP, and inhibition of PTHrP expression by small interfering RNA significantly increased PTH1R expression ... In conclusion, our study show that PTHrP , after its intracellular processing and secretion, promotes down-regulation of the PTH1R in VSMC, thereby regulating cell proliferation in an auto/paracrine fashion
Hochane et al., Endocrinology 2013 (Glomerulonephritis) : PTH1R activation by PTHrP ( 1-36 ) or PTH ( 1-34 ) had no effect on proliferation but improved MC survival