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PTHLH — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Garmey et al., Biol Reprod 2000
(Calcium Signaling) :
Transforming growth factor (TGF)-beta1 ( 100 ng/ml )
increased PTH-rp concentrations ( assayed by two-site immunoradiometric assay of culture media ) as well as corresponding
PTH-rp mRNA accumulation ( assessed by RT-PCR ) in a time dependent manner, with maximal responses of 3- to 5-fold at 96 h. TGF-beta1 dose-response studies revealed an ED ( 50 ) of 0
Pateder et al., Exp Cell Res 2000
:
Both
TGF-beta1 and cis-retinoic acid stimulation markedly
increased PTHrP mRNA levels, while BMP-2 and PTHrP stimulation decreased the expression of this transcript
Shenberger et al., Life Sci 2001
:
PTHrP secretion was measured at baseline and in
response to
TGF-beta1 using a immunoradiometric assay
Lindemann et al., J Biol Chem 2001
(Breast Neoplasms) :
In TGF beta receptor II- and Ets1-deficient, noninvasive MCF-7 breast cancer cells,
TGF beta 1 neither influenced endogenous PTHrP expression nor
stimulated the
PTHrP P3 promoter
Sellers et al., Mol Cell Endocrinol 2002
(Carcinoma, Squamous Cell...) :
In order to examine the mechanism of
TGFbeta1 mediated
PTHrP mRNA stability, a cell-free assay of mRNA degradation was utilized in which the degradation of in vitro transcribed mRNA incubated with cytoplasmic protein extracts from SCC2/88 treated with vehicle or TGFbeta1 was measured ... These studies revealed that
TGFbeta1 induced
PTHrP mRNA stability might be, in part, the result of cis acting sequences within the coding region of the PTHrP mRNA
Zuscik et al., J Orthop Res 2002
:
Independently, lead and
TGF-beta1 were without effect on BMP-6 expression, but
PTHrP significantly
suppressed it
Lindemann et al., Biochem J 2003
(Breast Neoplasms...) :
In invasive MDA-MB-231 breast cancer cells,
transforming growth factor beta regulated PTHrP synthesis is
mediated by an Ets1/Smad3 dependent activation of the
PTHrP P3 promoter
Sellers et al., Prostate 2004
(Prostatic Neoplasms) :
We examined the
effect of
transforming growth factor-beta1 ( TGF beta 1 ) on
PTHrP mRNA expression and PTHrP secretion in normal canine prostate epithelial cells ( PEC ) and stromal cells ( PSC ), and in canine prostate carcinoma cells ( PCC ) ... The
effect of
TGF beta 1 on
PTHrP mRNA expression was measured by Northern blot, and secretion of PTHrP into culture medium was measured by immunoradiometric assay ( IRMA ) ...
TGF beta 1 increased
PTHrP mRNA expression in a time- and dose dependent manner in PEC and in PCC ...
TGF beta 1 significantly
increased PTHrP secretion ( P < or = 0.05 ) into PEC but not PSC conditioned medium ...
TGF beta 1 increased
PTHrP mRNA expression in canine PEC and PCC, and decreased expression in PSC
Faucheux et al., Dev Dyn 2004
:
TGF beta1 in vitro
stimulated PTHrP synthesis by cells from blastema, perichondrium, and cartilage
Tenta et al., Horm Metab Res 2005
(Prostatic Neoplasms) :
Consequently, we have investigated whether IGF-1,
TGF-beta1 , bFGF, IL-6, zoledronic acid and/or dexamethasone
affect the expression of the
PTHrP and type I PTH/PTHrP receptor ( PTH.1R ) in PC-3 prostate cancer cells using relative quantitative PCR and real-time PCR ( expression at mRNA level ) and immunocytochemical and immunofluorescence analysis ( expression at protein level )
Tenta et al., Anticancer Res 2006
(Bone Neoplasms...) :
Whether IGF-1,
TGF beta 1 , bFGF, IL-6 and zoledronic acid
affect the expressions of
PTHrP and PTH.1R in MG-63 osteoblast-like osteosarcoma cells was investigated in this study ... Our data showed that primarily IGF-1,
TGF beta 1 and IL-6 ( up to 25 ng/ml for 48 h )
increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid ( up to 100 microM for 48 h ) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells
Ardura et al., J Am Soc Nephrol 2010
(Disease Models, Animal...) :
Here,
PTHrP ( 1-36 )
increased TGF-beta1 in cultured tubuloepithelial cells and TGF-beta blockade inhibited PTHrP induced EMT related changes, including upregulation of alpha-smooth muscle actin and integrin linked kinase, nuclear translocation of Snail, and downregulation of E-cadherin and zonula occludens-1 ... Inhibition of EGFR activation abolished these EMT related changes, the activation of ERK1/2, and
upregulation of
TGF-beta1 and VEGF by
PTHrP ( 1-36 )
Romero et al., Nephrol Dial Transplant 2010
(Diabetic Nephropathies...) :
In this condition, AngII induces the upregulation of
PTHrP , which might
induce the expression of
TGF-beta(1) and p27 ( Kip1 )
Tait et al., Cancer 1994
(Carcinoid Tumor...) :
TGF-beta 1 and EGF
regulation of
PTH-rP gene expression in squamous cell carcinomas of gynecologic origin is unique for each cell line studied and different from that in human lung carcinoid cells
Casey et al., J Clin Endocrinol Metab 1993
:
17 beta-Estradiol ( E2 ), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), endothelin-1 (ET-1),
transforming growth factor-beta 1 ( TGF beta 1 ), and serum
stimulated PTH-rP production ( evaluated by immunoassay of PTH-rP in the culture medium ) by these cells
McCauley et al., J Bone Miner Res 1995
:
Effects of differentiation and
transforming growth factor beta 1 on
PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells
Yasui et al., J Obstet Gynaecol Res 1997
(Cystadenocarcinoma, Papillary...) :
The
TGF-beta 1 significantly ( p < 0.05 )
stimulated intracellular
PTHrP production in a time dependent manner, also by Day 1
Li et al., Br J Oral Maxillofac Surg 1997
(Basal Cell Nevus Syndrome...) :
PTHrP may act synergistically with interleukin-1 to increase bone resorption or stimulate osteoblasts and
inhibit osteoclasts ( resulting in reduced resorption ) via its
transforming growth factor beta-like activity
McCauley et al., Mol Cell Endocrinol 1994
(Osteosarcoma) :
Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and
PTHrP binding in ROS 17/2.8 osteosarcoma cells ... These data indicate that
TGF-beta1 upregulates steady-state mRNA, ligand binding and
PTH/PTHrP receptor signaling in rat osteosarcoma cells
Werkmeister et al., Endocrine 1998
:
TGF-beta1 increased
PTHrP mRNA expression by normal keratinocytes in a dose dependent manner with maximal stimulation at 6-1 2 h after treatment