Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

DurĂ¡n et al., Mol Cell 2012 : Thus, mTORC1 senses and is activated by glutamine and leucine via glutaminolysis and a-ketoglutarate production upstream of Rag
Marc Rhoads et al., Amino Acids 2009 : In addition, glutamine and arginine stimulate the mitogen activated protein kinase and mammalian target of rapamycin (mTOR)/p70 ( s6 ) kinase pathways, respectively, to enhance mucosal cell migration and restitution
Chiu et al., Amino Acids 2012 : Thus, glutamine stimulates mTORC1 independent of cell leucine, suggesting the existence of two distinct stimulatory signals from either glutamine or EAA