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MTOR — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: RAC1/GTP complex (RAC1) → mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) (regulation of actin cytoskeleton organization, collaborate)
  Sarbassov et al., Curr Biol 2004, Jacinto et al., Nat Cell Biol 2004
  Evidence: mutant phenotype
• WikiPathways Target Of Rapamycin (TOR) Signaling: Complex of MLST8-MTOR-MAPKAP1-RICTOR → RAC1 (activation)

Text-mined interactions from Literome

Dunaway et al., Mol Cell Biol 2011 : Slit2 stimulates angiogenesis through mTORC2 dependent activation of Akt and Rac GTPase, the activities of which are inhibited in the presence of ephrin-A1
Wei et al., Cell Physiol Biochem 2013 : Moreover, both Rac1-GTPase overexpression and activation of mTOR by phosphatidic acid drastically blocked simvastatin induced autophagosome formation in CAMs
Saci et al., Mol Cell 2011 : Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size ... Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
Hernández-Negrete et al., J Biol Chem 2007 : Rapamycin, a widely used inhibitor of mTOR signaling , did not inhibit Rac activity and cell migration induced by leucine, indicating that P-Rex1, which we found associated to both mTOR complexes, is only active when in the mTORC2 complex