Gene interactions and pathways from curated databases and text-mining

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BDNF — RAC2

Text-mined interactions from Literome

Noga et al., Clin Exp Allergy 2007 (Hypersensitivity) : NGF led to decreased RhoA and increased Rac activation, while BDNF affected RhoA and Rac activity in a reciprocal fashion
Namekata et al., Proc Natl Acad Sci U S A 2010 : BDNF induces axonal sprouting through Dock dependent Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Mullen et al., Brain Res 2012 (MAP Kinase Signaling System) : Activation of Rac/cdc42/JNK signaling by BDNF may reduce the formation of neurites
Li et al., J Neurochem 2013 : In addition, GGT and its known substrate Rac was activated by BDNF , which promotes synaptogenesis in cultured hippocampal neurons