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ARF6 — RASA1
Text-mined interactions from Literome
Zhu et al., Mol Biol Cell 1999
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Because sensitivity to Tris extraction correlates well with nucleotide hydrolysis, this finding might suggest a possible link between MPR sorting and
ARF GAP regulation
Hu et al., Proc Natl Acad Sci U S A 2005
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Both PIKE-L and -A isoforms contain GTPase, pleckstrin homology (PH),
ADP ribosylation factor-GTPase activating protein, and two ankyrin repeats domains, and C-terminal ADP ribosylation
factor-GTPase activating protein activates its internal GTPase activity
Kruljac-Letunic et al., Methods Enzymol 2005
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Furthermore, an assay to study cellular
Arf activation and thus
GAP as well as guanine nucleotide exchange factor (GEF) activities and their regulation is described
Kanamarlapudi et al., J Biol Chem 2012
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We found that human CG ( HCG ) -induced HLHCGR internalization, cAMP accumulation and
ARF6 activation were
inhibited by Gallein ( ß? inhibitor ), Wortmannin ( PI 3-kinase inhibitor ), SecinH3 ( cytohesin ARF GEF inhibitor ), QS11 ( an ARF
GAP inhibitor ), an ARF6 inhibitory peptide and ARF6 siRNA
Cavenagh et al., J Biol Chem 1994
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Purified recombinant human Arl3 was shown to bind guanine nucleotides but lacks ARF activity and intrinsic or
ARF GTPase activating protein stimulated GTPase activity