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ERVK-6 — RHO

Text-mined interactions from Literome

Scott et al., J Invest Dermatol 2003 : We explored the signaling mechanisms of proteinase activated receptor-2 mediated Rho activation in human keratinocytes and show that activation of proteinase activated receptor-2, either through specific proteinase activated receptor-2 activating peptides or through trypsinization, elevates cAMP in keratinocytes
Blum et al., Am J Physiol Cell Physiol 2008 : In this study we assessed the role of Rho-family GTPase signaling as an additional pathway for the regulation of ATP release in response to activation of protease activated receptor-1 (PAR1) , lysophosphatidic acid receptor ( LPAR ), and M3-muscarinic ( M3R ) GPCRs. Thrombin ( or other PAR1 peptide agonists ), LPA, and carbachol triggered quantitatively similar Ca ( 2+ ) mobilization responses, but only thrombin and LPA caused rapid accumulation of active GTP bound Rho