Gene interactions and pathways from curated databases and text-mining

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RICTOR — RICTOR

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Julien et al., Mol Cell Biol 2010 : In addition, phosphorylation of the Akt substrates FoxO1/3a and glycogen synthase kinase 3 alpha/beta ( GSK3 alpha/beta ) was found to be increased in these cells, indicating that S6K1 mediated phosphorylation of Rictor inhibits mTORC2 and Akt signaling
Glidden et al., J Biol Chem 2012 : Although Rictor is required for the stability and activity of mTORC2 , little is known about functional regions or post-translational modifications within Rictor that are responsible for regulating mTORC2
Treins et al., Oncogene 2010 : Rictor phosphorylation at Thr1135 does not lead to major changes in mTORC2-kinase activity
Wang et al., Oncogene 2008 (Prostatic Neoplasms) : Inhibition of both mTORC1 and mTORC2 by rapamycin induced apoptosis, whereas rapamycin-stimulation of AR transcriptional activity resulted from the inhibition of mTORC1, but not mTORC2
Mazei-Robison et al., Neuron 2011 : Chronic morphine decreases mTORC2 activity, and overexpression of Rictor , a component of mTORC2, prevents morphine induced changes in cell morphology and activity