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AKT3 — RLN2

Text-mined interactions from Literome

Moore et al., Endocrinology 2007 (Cardiomegaly) : Further analysis showed that activation of Akt ( 1.8-fold, P < 0.001 ) and ERK ( 2.0-fold, P < 0.01 ) were involved in the antiapoptotic action of H2-relaxin in CM, and that Gi/o coupling of relaxin receptors was associated with the H2-relaxin induced Akt activation in CM
Liu et al., Oncogene 2008 (Prostatic Neoplasms) : Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus
Dschietzig et al., Regul Pept 2009 : Native porcine relaxin , but not the modified peptide affected RXFP1 dependent and GR-independent readouts : ERK-1/2 and Akt phosphorylation as well as up-regulation of Akt and endothelin type-B receptor
Ahmad et al., Mol Cell Endocrinol 2012 : Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K, Akt , ERK and PKC-? and the transcription factors Elk-1, c-fos and, to a lesser extent, NF-?B are involved in relaxin 's induction of MMP-9