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IFNG — RPL17
Text-mined interactions from Literome
Li et al., Acta Biochim Biophys Sin (Shanghai) 2004
:
The results suggested that
GST-PD-1 could competently block the interaction between PD-L1 and PD-1 and
increase the production of IL-2 and
IFN-gamma of phytohemagglutinin activated T cells
Cai et al., Cell Immunol 2004
:
PD-1 ligand blockade modestly
enhanced the percentage of responding T cells and production of
IFN-gamma in a primary response to myelin basic protein (MBP) in normal donors
Ariel et al., J Biol Chem 2005
(Inflammation...) :
PD1 blocked T cell migration in vivo,
inhibited tumor necrosis factor alpha and
interferon-gamma secretion, and promoted apoptosis mediated by raft clustering
Maier et al., J Immunol 2007
(Hepatitis B, Chronic) :
To determine whether
PD-1 plays a role in the functional suppression of
IFN-gamma secretion by CTLs, we treated HBV transgenic mice with blocking Abs specific for PD ligand (PD-L)1, the most widely expressed PD-1 ligand, and adoptively transferred HBV-specific CTLs. Treatment with anti-PD-L1 Abs resulted in a delay in the suppression of IFN-gamma producing CTLs and a concomitant increase in the absolute number of IFN-gamma producing CTLs in the liver
Wahl et al., Gastroenterology 2008
:
In contrast, the
PD-1/B7-H1 interaction
inhibited proliferation and
interferon-gamma release of effector/memory CD8 T blasts specifically restimulated by peptide pulsed HC
Babu et al., J Infect Dis 2009
(Filariasis...) :
Blockade of CTLA-4 restored production of both IFN-gamma and IL-17, whereas
PD-1 blockade
restored IFN-gamma production only
Rosignoli et al., Clin Exp Immunol 2009
(HIV Infections) :
The
effect of
PD-1 and PD-L1 blockade on proliferation and
interferon (IFN)-gamma production was tested on eight HIV-1 ( + ) patients
Figueira et al., J Periodontol 2009
(Alveolar Bone Loss...) :
These data show that
PD-1 engagement could be
involved in the modulation of
IFN-gamma production by T cells in patients with chronic periodontitis