Gene interactions and pathways from curated databases and text-mining

◀ Back to TSC1

RPS6KB1 — TSC1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RPS6KB1 → Complex of TSC1-TSC2 (decreases, TSC1/TSC2 Activity, RPS6KB1 Activity)
    Evidence: Furthermore, in insulin- or serum-stimulated cells, activation of p70S6K is inhibited by expression of the Tsc1-Tsc2 complex [54,55]. This finding demonstrates that the introduction of a genetic inhibitor of mTOR, downstream of Akt1, inhibits the activation of p70S6K, adding genetic evidence for an Akt1-mTOR-p70S6K pathway.

Text-mined interactions from Literome

Tee et al., Proc Natl Acad Sci U S A 2002 (Tuberous Sclerosis) : Second, the activity of S6K1 was repressed by coexpression of hamartin and tuberin, but the activity of rapamycin-resistant mutants of S6K1 were not affected, implicating mTOR in the TSC mediated inhibitory effect on S6K1
Jaeschke et al., J Cell Biol 2002 (Tuberous Sclerosis) : Although activation of wild-type S6K1 and cell proliferation in TSC2-deficient cells is dependent on the mammalian target of rapamycin (mTOR), by using an S6K1 variant ( GST-DeltaC-S6K1 ), which is uncoupled from mTOR signaling, we demonstrate that TSC1-2 does not inhibit S6K1 via mTOR