Gene interactions and pathways from curated databases and text-mining

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MAPK1 — RPTOR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dormond-Meuwly et al., Biochem Biophys Res Commun 2011 (Neoplasms...) : Downregulation of mTORC1 but not mTORC2 had similar effects showing that the inhibition of mTORC1 is responsible for the activation of MAPK ... Taken together these results show that blocking mTORC1 in endothelial cells activates MAPK and that a combined inhibition of MAPK and mTOR has additive anti-angiogenic effects
James et al., Mol Cell Biol 2009 (Meningioma...) : Merlin does not regulate mTORC1 via the established mechanism of phosphoinositide 3-kinase-Akt or mitogen activated protein kinase/extracellular signal regulated kinase mediated TSC2 inactivation and may instead regulate TSC/mTOR signaling in a novel fashion ... Merlin does not regulate mTORC1 via the established mechanism of phosphoinositide 3-kinase-Akt or mitogen activated protein kinase/extracellular signal regulated kinase mediated TSC2 inactivation and may instead regulate TSC/mTOR signaling in a novel fashion
Williamson et al., Am J Physiol Endocrinol Metab 2006 (MAP Kinase Signaling System) : Overall, the data support the conclusion that AICAR induced AMPK activation suppresses protein synthesis through concurrent repression of mTOR signaling and activation of MAPK signaling, the combination of which modulates transient changes in the initiation and elongation phases of mRNA translation
Gulhati et al., Carcinogenesis 2012 (Colorectal Neoplasms...) : In this study, we show that inhibition of mTORC1 with rapamycin leads to feedback activation of PI3K/Akt and Ras-MAPK signaling, resulting in cell survival and possible contribution to rapamycin resistance
Carracedo et al., J Clin Invest 2008 (MAP Kinase Signaling System...) : Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K dependent feedback loop in human cancer ... Taken together, our findings identify MAPK activation as a consequence of mTORC1 inhibition and underscore the potential of a combined therapeutic approach with mTORC1 and MAPK inhibitors, currently employed as single agents in the clinic, for the treatment of human cancers