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IFNG — RUNX3

Text-mined interactions from Literome

Djuretic et al., Nat Immunol 2007 : Here we show that the transcription factor Runx3 is induced in T helper type 1 ( T ( H ) 1 ) cells in a T-bet dependent manner, and that both transcription factors T-bet and Runx3 are required for maximal production of interferon-gamma (IFN-gamma) and silencing of the gene encoding interleukin 4 (Il4) in T ( H ) 1 cells
Cruz-Guilloty et al., J Exp Med 2009 : Runx3 regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program : IFN-gamma , perforin, and granzyme B
Yagi et al., Immunity 2010 : The transcription factor GATA3 actively represses RUNX3 protein regulated production of interferon-gamma ... GATA3 overexpression blocked Runx3 mediated Eomes induction and IFN-gamma production, and GATA3 protein physically interacted with Runx3 protein ... Furthermore, we found that Runx3 directly bound to multiple regulatory elements of the Ifng gene and that blocking Runx3 function in either Th1 or GATA3-deficient `` Th2 '' cells results in diminished IFN-gamma production by these cells