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RAC1 — S1PR1

Pathways - manually collected, often from reviews:

• NCI Pathway Database S1P1 pathway: S1P1/S1P complex (S1PR1) → RAC1/GDP complex (RAC1) (modification, activates) Paik et al., J Biol Chem 2001, Matsuyuki et al., Cell Mol Immunol 2006*
  Evidence: mutant phenotype, assay
• NCI Pathway Database S1P1 pathway: S1P1/S1P complex (S1PR1) → RAC1/GTP complex (RAC1) (modification, activates) Paik et al., J Biol Chem 2001, Matsuyuki et al., Cell Mol Immunol 2006*
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Takuwa et al., Biochim Biophys Acta 2002 : Consistent with this, Edg1 and Edg3, and Edg5 regulate the activity of the Rho family GTPase Rac positively and negatively, respectively
Singleton et al., Circ Res 2009 (Disease Models, Animal...) : Silencing ( small interfering RNA ) Akt expression blocked OxPAPC mediated S1P(1) activation ( threonine phosphorylation ), whereas silencing S1P(1) receptor expression blocked OxPAPC mediated Tiam1 recruitment to CEMs, Rac1 activation, and EC barrier enhancement
Takuwa et al., American journal of cancer research 2011 : S1PR1 and S1PR3 mediate directed cell migration toward S1P through coupling to G ( i ) and activating Rac , a Rho family small G protein essential for cell migration ... In sharp contrast, S1PR2 mediates S1P inhibition of Rac at the site downstream of G ( 12/13 ) -mediated Rho activation, thus identified as the first G protein coupled receptor that negatively regulates Rac and cell migration